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Profhilo vs Polynucleotides: What’s the Difference and Which Is Right for You?
- Oxford Cosmetic Clinic
- Apr 23
- 2 min read
If you have been exploring advanced skin rejuvenation treatments, you’ve likely come across Profhilo and polynucleotides. While both are used for skin rejuvenation, they work through fundamentally different biological mechanisms.
At our doctor-led aesthetic clinic in Oxfordshire, we’re often asked: Which treatment is better? The answer really depends on your skin concerns and goals.
In this guide, we’ll break down the key differences between Profhilo and polynucleotides so you can make an informed decision.
What Is Profhilo?
Profhilo is a revolutionary anti-ageing treatment designed to improve skin quality. Profhilo contains one of the highest concentrations of hyaluronic acid (HA) available, a substance naturally found in the skin that retains moisture and promotes collagen production.
Unlike dermal fillers, Profhilo doesn’t add volume or change facial contours. Instead, it spreads beneath the skin to deeply hydrate and stimulate collagen and elastin production.
Clinical evidence shows that Profhilo works by:
Stimulating fibroblast activity, increasing collagen and elastin production
Improving skin hydration, elasticity, and dermal density
Enhancing overall skin texture and reducing laxity
Key Benefits of Profhilo:
Improves skin hydration and radiance
Boosts collagen and elastin
Smooths fine lines and crepey skin
Creates a natural “glow”
Best used for:
Early signs of ageing
Dull, dehydrated skin
Mild skin laxity (looseness)
What Are Polynucleotides?
Polynucleotides are regenerative injectable treatments made up from DNA fragments. Rather than simply hydrating the skin, polynucleotides work at a cellular level to repair, regenerate, and reduce inflammation.
They work at a deeper biological level by:
Supporting cellular repair pathways
Enhancing fibroblast activity and angiogenesis
Improving the skin’s structural integrity over time
Key Benefits of Polynucleotides:
Promote tissue repair and regeneration
Stimulate collagen production
Improve skin quality and elasticity
Exhibit anti-inflammatory and wound-healing properties
Best For:
Sensitive or damaged skin
Acne scarring or rosacea-prone skin
Under-eye rejuvenation
Thinner, ageing skin requiring repair
Profhilo vs Polynucleotides: Key Differences
Mechanism of Action
Profhilo: Hydrates and stimulates collagen through hyaluronic acid
Polynucleotides: Repair and regenerate skin at a cellular level
Treatment Goal
Profhilo: Skin hydration and glow
Polynucleotides: Skin healing and regeneration
Evidence-Based Results
Profhilo: Improved hydration, elasticity, and wrinkle reduction
Polynucleotides: Enhanced tissue regeneration, collagen synthesis, and skin quality
Treatment Areas
Profhilo: Face, neck, hands
Polynucleotides: Face, under-eyes, neck, and delicate areas
Which Treatment Is Better?
There’s no one-size-fits-all answer.
Choose Profhilo if your goal is:
Skin hydration
Improved elasticity
Subtle, natural rejuvenation
Choose polynucleotides if your goal is:
Skin repair and regeneration
Improving damaged or inflamed skin
Strengthening thin or ageing skin
In many cases, combination therapy may be appropriate. Using Profhilo for hydration and polynucleotides for regeneration, based on a full skin assessment.
Why Choose a Doctor-Led Clinic in Oxfordshire?
Injectable treatments like Profhilo and polynucleotides require a deep understanding of facial anatomy, skin biology, and medical safety.
A doctor-led clinic ensures:
Treatments are performed by qualified medical professionals
Safe administration based on facial anatomy and evidence-based protocols
You receive a personalised, evidence-based plan
Management of risks and complications
Book a Consultation
If you’re considering Profhilo or polynucleotides in Oxfordshire, the best way to decide is through a personalised consultation.
One of our expert doctors will assess your skin, discuss your goals, and recommend the most effective treatment plan for you.
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